Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure
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چکیده
منابع مشابه
Pulsatile Hyperglycaemia Induces Vascular Oxidative Stress and GLUT 1 Expression More Potently than Sustained Hyperglycaemia in Rats on High Fat Diet
INTRODUCTION Pulsatile hyperglycaemia resulting in oxidative stress may play an important role in the development of macrovascular complications. We investigated the effects of sustained vs. pulsatile hyperglycaemia in insulin resistant rats on markers of oxidative stress, enzyme expression and glucose metabolism in liver and aorta. We hypothesized that liver's ability to regulate the glucose h...
متن کاملPrior exposure to hyperglycaemia attenuates the relationship between glycaemic variability during critical illness and mortality.
OBJECTIVE Our primary objective was to determine the impact of prior exposure to hyperglycaemia on the association between glycaemic variability during critical illness and mortality. Our secondary objectives included evaluating the relationships between prior hyperglycaemia and hyperglycaemia or hypoglycaemia during critical illness and mortality. DESIGN AND PARTICIPANTS A single-centre, ret...
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Stress hyperglycaemia is a distinctive clinical feature of critical illness. Stress mediators, namely stress hormones, cytokines and the central nervous system, interfere with normal carbohydrate metabolism, especially in the liver and skeletal muscle. Central insulin resistance, defined as increased hepatic gluconeogenesis and glucose output despite abundant endogenous insulin levels, appears ...
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Oxidative stress plays a pivotal role in the development of diabetes and hyperglycaemia. The protective effects of natural extracts against diabetes are mainly dependent on their antioxidant and hypoglycaemic properties. Broccoli (Brassica oleracea) exerts beneficial health effects in several diseases including diabetes; however, the mechanism has not been elucidated yet. The present study was ...
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ژورنال
عنوان ژورنال: Diabetes and Vascular Disease Research
سال: 2011
ISSN: 1479-1641,1752-8984
DOI: 10.1177/1479164111421033